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About Malaria

 

Faculty

 
Clive J Shiff
Associate Professor
Academic Degrees
PhD, Rhodes University, 1964
Departmental Affiliation
Molecular Microbiology and Immunology
Departmental Address
615 North Wolfe St, Suite E5142
Baltimore, MD 21205
Phone: 410-955-1263
Fax: 410-955-0105
Research and Professional Experience

My main research interests are in the study of tropical parasitic diseases particularly schisosomiasis and malaria under African conditions. With schistosomiasis, I am currently involved in assessing the importance of bladder cancer associated with infection of the urinary schistosome (S.haematobium). Bladder cancer associated with the parasite is different from bladder cancer seen in non endemic areas. It is squamous cell carcinoma and we hope to investigate the etiological processed involved and to see why there is this difference between parasite derived disease and the common form of bladder cancer. These studies are under way in Ghana and we hope to extend them to Zambia where a genetically different strain of the parasite occurs. It is important to see if there are differences in the pathogenicity of these two forms of S. haematobium. There is no animal model presently available, so the work must be done in endemic areas. I am interested in the effect of chronic infection among adults. It is important to show the epidemiological importance of this infection is in endemic areas. I have recently developed a novel means to dignose chronic schistosome infections accurately

Additionally, I have strong interests in malaria epidemiology and control and medical entomology . Currently I am the PI and lead scientist running the Malaria Institute at Macha, Zambia. This functions as a core facility for the Research community at Johns Hopkins University, with accent on field research. Use of sinple technologies to develop time senstiitive data sets describing malaria epidemilogy has enabled us talk about sustainable control of malaria based on data from rural health centres. We plan to train local university faculty in outbreak epidemiology so as to increase local expertise in data colection and analysis.  I have recently been invited to join the WHO Expert Committee on Integrated Vector Control, and the UNEP Committee on DDT and its use against malaria

Keywords

Molecular Microbiology and Immunology, Urinary schistosomiasis, bladder cancer, malarai epidemilogy and malaria control, DDT, medical entomology

Honors and Awards

Member UNEP panel "Global partnership to develop alternatives to DDT". 2004: 2008.

WHO

Selected Publications

 

Ibironke, O. A., Phillips, A.E., Garba, A., Lamine, S.M. Shiff, C.J. 2011 "Diagnosis of Schistosoma haematobium by detection of specific DNA fragments from filtered urine samples." American Journal of Tropical Medicine and Hygiene 84.6 (2011): 998-1001.

Kamanga, A., Moono, P., Stresman, G., Mharakurwa, S., Shiff, C. (2010) "Rural health centres, communities and malaria case detection in Zambia using mobile telephones: a means to detect potential reservoirs of infection in unstable transmission conditions." Malar J 9 (2010): 96.

Koukounari, A., Wenster, J., Donnelly, CA., Bethany, C., Naples, J., Bosompem, K., Shiff, C.( 2009) "Sensitivities and Specificities of Diagnostic Tests and Infection Prevalence of Schistosoma haematobium Estimated from Data on Adults in Villages Northwest of Accra, Ghana." American Journal of Tropical Medicine and Hygiene 80.3 (2009): 435-41.

Mharakurwa, S., et al. "PCR detection of Plasmodium falciparum in human urine and saliva samples." Malar J 5 (2006): 103.

Naples, J., Isharwah, S., Shiff, C.J., Bosompem, K.M., Vetri, R.W.  (2009)Clinical Utility os squamous and transitional nuclear structure alterations induced by Schistosoma haematobium in chronical infected adults with bladder damage verified by ultrasound in Ghana. 2009  Analytical and Quantitative Cytology and Histology. 31: 143-  151.

Shiff, Clive, Veltri, Robert, Naples, Jean and others (2006) Ultrasound verification of bladder damage is associated with known biomarkers of bladder cancer in adults chronically infected with Schistosoma haematobium in Ghana.. Trans. R. Soc. Trop. Med. Hyg. 100: 847-854.

Koukounari, A., Webster, J., Donnelly, C., Bray, B., Naples, J, Bosompem, B and Shiff, C. (2009) Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages Northwest of Accra, Ghana. American Journal of Tropical Medicine and Hygiene 80: 435-441

Chimbari, M. and Shiff, CJ. (2008) A laboratory assessment of the potential molluscicidal effect of Jatropha curcas aqueous extracts. African Journal of Aquatic Science 33: 269-273.

 Brouwer, KC., Ndhlovu, P., Munatsi, A and Shiff, CJ. (2001) Genetic Diversity of a population of Schistosoma haematobium derived from school children in east central Zimbabwe. J. Parasitol 87: 762-769.

Shiff, C.J. (2002) Integrated approach to malaria control: Clinical Microbiology Reviews 15: 278-293.

Brouwer, KC., Ndhlovu, P.,Wagatsuma, Y., Munatsi, A and Shiff, CJ.(.2003) Genetic diversity of Schistosoma haematobium in relation to urinary tract morbidity in Zimbabwean schoolchildren American Journal Tropical Medicine and Hygiene 68: 456-462

Ahmed, AAM., Babiker, A., Eltash, LA and Shiff, CJ. (2002) Development of a modified baited trap for the detection of Schistosome cercariae using natural oils rich in polyunsaturated fatty acids in Sudan. Acta Tropica 82: 363-368.

Brouwer, KC., Ndhlovu, P.,Wagatsuma, Y., Munatsi, A and Shiff, CJ..(2003) Epidemiological assessment of Schistosoma haematobium induced kidney and bladder pathology in rural Zimbabwe Acta Tropica 85: 339-347.

Shiff, C. (2004) Efficacy of sulfadoxine-pyrimethamine as a first line treatment for malaria declining in Malawi (Commentary Author) Evidenced Base Health Care & Public Health. 8: 280-83.

Brouwer,KC.; Munatsi,A; Ndhlovu,P.; Wagatsuma,Y; Shiff,C.J (2004) .Urinary schistosomiasis in Zimbabwean school children: predictors of morbidity. African Health Science 4: 115-118

Naples, Jean Marie, Shiff, Clive and Halden Rolfe, U. (2005) Reduction of infectivity of schistosome cercariae by application of cercaricidal oil to water. Am. J. Trop. Med. Hyg. 73: 956-961.

Simoloka, S., Thuma, P., Shiff, C. and Sullivan D. (2006). PCR detection of Plasmodium falciparum in human saliva and urine. Malaria Journal Nov 8. 5. 103.

 

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