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Johns Hopkins Malaria Research Institute


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About Malaria



Marcelo Jacobs-Lorena
Academic Degrees
Bsc (1964) Chemistry, Sào Paulo Univ., Brazil; MSc (1967) Biochemistry, Osaka University, Japan; PhD (1972) Biology, Massachusetts Institute of Technology, U.S.A.
Departmental Affiliation
Molecular Microbiology and Immunology
Departmental Address
615 North Wolfe St, Suite E5132
Baltimore, MD 21205
Phone: 443-287-0839
Fax: 410-955-0105
Research and Professional Experience

Mosquitoes as Vectors for the Malaria Parasite

Our research covers four topics:

o Genetic modification of mosquito vectorial capacity o Mosquito-Plasmodium interactions o Gene expression during Plasmodium development in the mosquito o Structure and function of the peritrophic matrix (PM)


  • malaria
  • mosquitoes
  • transgenesis
  • Plasmodium-mosquito interacions
  • peritrophic matrix

Honors and Awards

Selected Publications

Srinivasan P, Coppens I and Jacobs-Lorena M (2008) Distinct roles of Plasmodium Rhomboid 1 in parasite development and malaria pathogenesis. PLoS Pathogens 5(1) e1000262.

Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N and Jacobs-Lorena M (2008) Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathogens, 5(1)e1000265.

Dinglasan RR, Devenport M, Florens L, Johnson JR, McHugh CA, Donnelly-Doman, M, Carucci DJ, Yates JR. III and Jacobs-Lorena, M (2008) The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect Biochem. Mol. Biol, in press.

Srinivasan P, Fujioka H and Jacobs-Lorena M (2008) PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito. Cell. Microbiol. 10:1304-1312.

Li C, Marrelli MT, Yan G and Jacobs-Lorena M (2008) Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. J. Hered. 99:275-282.

Yoshida S, Shimada Y, Kondoh D, Kouzuma Y, Ghosh AK, Jacobs-Lorena M and Sinden RE (2007) Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development. PLOS Pathogens, 3(12)e192:1962-1970.

Dinglasan RR, Alaganan A, Ghosh AK, Saito A, van Kuppervelt TH and Jacobs-Lorena M (2007) Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion. Proc. Natl. Acad. Sci. USA. 104:15882-15888.

Sodja A, Fujioka H, Lemos FJA, Donnelly-Doman M and Jacobs-Lorena M (2007) Induction of actin gene expression in the mosquito midgut by blood ingestion correlates with striking changes of cell shape. J. Insect Physiol. 53:833-839.

Dinglasan RR, Kalume DE, Kanzok SM, Ghosh AK, Muratova O, Pandey A and Jacobs-Lorena M (2007) Characterization of a novel, conserved Plasmodium transmission-blocking mosquito midgut antigen. Proc. Natl. Acad. Sci. USA 104:13461-13466.

Marrelli MT, Li C, Rasgon J and Jacobs-Lorena M (2007) Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood. Proc. Natl. Acad. Sci. USA. 104:5580-5583.

Riehle MA, Moreira CK, Lampe D, Lauzon C and Jacobs-Lorena M (2007) Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut. Int. J. Parasit. 37:595-603.

Devenport M, Alvarenga PH, Shao L, Fujioka H, Oliveira PL and Jacobs-Lorena M (2006) The Aedes aegypti peritrophic matrix protein, AeIMUC1, binds chitin and heme. Biochemistry, 45:9540-9549.

Abraham EG, Pinto S, Ghosh A, Vanlandingham DL, Budd A, Higgs S, Kafatos FC, Jacobs-Lorena M, Michel K (2005) An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proc. Natl. Acad. Sci. USA. 102:16327–16332.

Xu X, Dong Y, Abraham EG, Kocan A, Srinivasan P, Ghosh AK, Sinden RE, Ribeiro JM, Jacobs-Lorena M, Kafatos FC and Dimopoulos G. (2005) Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol. Biochem. Parasitol. 142:76-87.

Shao L, Devenport M, Fujioka H, Ghosh A and Jacobs-Lorena M (2005) Identification and characterization of a novel peritrophic matrix protein, Ae-APER50, and the microvillar membrane protein, AEG12, from the mosquito, Aedes aegypti. Insect Biochem. Mol. Biol, 35:947-959.

Abraham EG, Donnelly-Doman M, Fujioka H, Ghosh A, Moreira L and Jacobs-Lorena M (2005) Driving midgut-specific expression and secretion of a foreign protein in transgenic mosquitoes with AgAper1 regulatory elements. Insect Mol. Biol., 14:271-279.

Devenport M, Fujioka H, Donnelly-Doman M, Shen Z and Jacobs-Lorena M (2005) Storage and secretion of Ag-Aper14, a novel peritrophic matrix protein, and Ag-Muc1 from the mosquito Anopheles gambiae. Cell Tissue Res. 320:175-185.

Devenport M, Fujioka H and Jacobs-Lorena M (2004) Storage and secretion of the peritrophic matrix protein Ag-Aper1 and trypsin in the midgut of Anopheles gambiae. Insect Mol. Biol. 13:349-358.

Moreira LA, Wang J, Collins FH and Jacobs-Lorena M (2004) Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development. Genetics 166:1337–1341.

Srinivasan P, Abraham EG, Ghosh AK, Valenzuela J, Ribeiro JMC, Dimopoulos G, Kafatos FC, Adams JH and Jacobs-Lorena M (2004) Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation. J. Biol. Chem. 279:5581-5587.

Abraham EG, Islam S, Srinivasan P, Ghosh AK, Valenzuela J, Ribeiro JMC, Kafatos FC, Dimopoulos G, and Jacobs-Lorena M (2004) Analysis of the Plasmodium and Anopheles transcriptional repertoires during ookinete development and midgut invasion. J. Biol. Chem. 279:5573-5580.


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