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Faculty
| George Dimopoulos, PhD |
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"I arrived at the Bloomberg School of Public Health in August 2003, and through the JHMRI's excellent support system, my laboratory was soon generating research data. The academic and scientific environments are of the highest standards and provide research seminars, state-of-the-art facilities and opportunities for interaction with other investigators. The JHMRI has enabled me to initiate cutting-edge projects that are currently funded by the NIH/NIAID and other funding agencies."
George Dimopoulos and his team are studying interactions between the malaria parasite Plasmodium and its vector mosquito Anopheles, with a particular interest in mechanisms of the mosquito's immune system implicated in killing parasites. The researchers are employing high throughput transcription analyses of thousands of mosquito genes to define and characterize mosquito responses to components of Plasmodium-infected blood. These analyses will permit selection of key candidate defense genes for further functional characterization. They have already identified a pattern recognition receptor family of genes that is likely to participate in Plasmodium killing, and several members of this gene family are now being molecularly characterized. We have discovered complex relationships between the mosquito’s antimicrobial and anti-Plasmodium defense systems.
Johns Hopkins Bloomberg School of Public Health
615 North Wolfe Street
Room E4630
Baltimore, MD 21205
email: gdimopou@jhsph.edu
phone: 443-287-0128
fax: 410-955-0105
LINKS
SELECTED PUBLICATIONS
Waterhouse, RM, Kriventseva, EV, Meister, S, Xi, Z, Alvarez, KV, Bartholomay, LC, Barillas-Mury, C, Bian, G, Blandin, S, Christensen, BM, Dong, Y, Jiang, H, Kanost, MR, Koutsos, AC, Levashina, EA, Li, J, Ligoxygakis, P, MacCallum, RM, Mayhew, GF, Mendes, A, Michel, K, Osta, MA, Paskewitz, S, Shin SW, Vlachou, D, Wang, L, Wei, W, Zheng, L, Zou, Z, Severson, DW, Raikhel, AS, Kafatos, FC, Dimopoulos, G, Zdobnov, EM, Christophides, GK (2007) Evolutionary dynamics of immune-related genes and pathways in disease vector mosquitoes. Science, 316:1738-1743.
Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu ZJ, Loftus B, Xi Z, Megy K, Grabherr M, Ren Q, Zdobnov EM, Lobo NF, Campbell KS, Brown SE, Bonaldo MF, Zhu J, Sinkins SP, Hogenkamp DG, Amedo P, Arsenburger P, Atkinson PW, Bidwell S, Biedler J, Birney E, Bruggner RV, Costas J, Coy MR, Crabtree J, Crawford M, Debruyn B, Decaprio D, Eiglmeier K, Eisenstadt E, El-Dorry H, Gelbart WM, Gomes SL, Hammond M, Hannick LI, Hogan JR, Holmes MH, Jaffe D, Johnston SJ, Kennedy RC, Koo H, Kravitz S, Kriventseva EV, Kulp D, Labutti K, Lee E, Li S, Lovin DD, Mao C, Mauceli E, Menck CF, Miller JR, Montgomery P, Mori A, Nascimento AL, Naveira HF, Nusbaum C, O'leary SB, Orvis J, Pertea M, Quesneville H, Reidenbach KR, Rogers YH, Roth CW, Schneider JR, Schatz M, Shumway M, Stanke M, Stinson EO, Tubio JM, Vanzee JP, Verjovski-Almeida S, Werner D, White O, Wyder S, Zeng Q, Zhao Q, Zhao Y, Hill CA, Raikhel AS, Soares MB, Knudson DL, Lee NH, Galagan J, Salzberg SL, Paulsen IT, Dimopoulos G, Collins FH, Bruce B, Fraser-Liggett CM, Severson DW. (2007)Genome Sequence of Aedes aegypti, a Major Arbovirus Vector. Science, 316:1718-1723.
Warr, E., Aguilar, R., Dong, Y. and Dimopoulos G. (2007) Transcriptome and proteome dissection of the Anopheles gambiae midgut. BMC Genomics, 8:37.
Baton, L., Dong, Y., Li, J. and Dimopoulos G. (2006) Variation in mosquito immunity to Plasmodium. Proceedings of the 11th International Congress of Parasitology
Dong Y., Aguilar R., Xi Z., Warr E., Mongin E., and Dimopoulos, G. (2006) Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. PLoS Pathogens 6: 1-13.
Dong Y., Taylor H.E., and Dimopoulos G. (2006) AgDscam, a hyper variable immunoglobulin domain containing receptor of the Anopheles gambiae innate immune system. PLoS Biology 4: e229
Mair G., Braks J.A.M., Garver L., Wiegant J.K.A.G., Hall Dirks, R.W., Khan S.M., Dimopoulos G., Janse C.J., Waters A.P. (2006) Regulation of sexual development of Plasmodium by translational repression. Science, 313(5787):667-669.
Warr, E., Lambrechts, L., Bourgouin C., Koella, J., and Dimopoulos G. (2006) Melanization of Sephadex Beads in Anopheles gambiae is controlled by anti-Plasmodium immune factors. Insect Biochemistry and Molecular Biology, 36:769-778
Aguilar R, Dong Y, Warr E, Dimopoulos G. Anopheles infection responses; laboratory models versus field malaria transmission systems. Acta Trop 95:285-91, 2005. Abstract
Aguilar R, Jedlicka AE, Mintz M, Mahairaki V, Scott AL, Dimopoulos G. Global gene expression analysis of Anopheles gambiae responses to microbial challenge. Insect Biochem Mol Biol 35:709-719, 2005.
Both M, Eckert SE, Csukai M, Muller E, Dimopoulos G, Spanu PD. Transcript profiles of Blumeria graminis development during infection reveal a cluster of genes that are potential virulence determinants. Mol Plant Microbe Interact 18:125-133, 2005.
Heard NA, Holmes CC, Stephens DA, Hand DJ, Dimopoulos G. Bayesian coclustering of Anopheles gene expression time series: Study of immune defense response to multiple experimental challenges. Proc Natl Acad Sci USA 102:16939-44, 2005. Article
Abraham EG, Islam S, Srinivasan P, Ghosh AK, Valenzuela J, Ribeiro JMC, Kafatos FC, Dimopoulos G, Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptional repertoires during ookinete development and midgut invasion. J Biol Chem 279:5573-5580, 2004. Abstract
Srinivasan P, Abraham EG, Ghosh AK, Valenzuela J, Ribeiro JMC, Dimopoulos G, Kafatos FC, Adams JH, Fujioka H, Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation. J Biol Chem 279:5581-5587, 2004. Abstract
Wu M-H, Dimopoulos G, Mantalaris A, Varley J. The effect of hyperosmotic pressure on antibody production and expression in the GS-NS0 cell line. Biotechnol Appl Biochem 40:41-46, 2004. Abstract
Dessens JT, Sidén-Kiamos I, Jmendoza J, Mahairaki V, Khater E, Vlachou D, Xu JX, Kafatos FC, Louis C, Dimopoulos G, Sinden RE. SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development. Cell Microbiol Mol Microbiol 49:319-329, 2003. Abstract
Dimopoulos G. Insect immunity and its implication in mosquito-malaria interactions. Microreview Cell Microbiol 5:3-14, 2003. Abstract
Kumar S, Christophides GK, Cantera R, Charles B, Han YS, Meister S, Dimopoulos G, Kafatos FC, Barillas-Mury C. The role of Reactive Oxygen Species (ROS) on Plasmodium melanotic encapsulation in Anopheles gambiae. Proc Natl Acad Sci USA 100:14139-14144, 2003. Article
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