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Monday, March 17
8:00 Continental Breakfast
8:30 Welcome Peter Agre
Dean Michael Klag
Session I. Parasite Biology George Dimopoulos
Moderator
8:40 From genes to drugs and vaccines: Designing David Roos
and mining pathogen genome databases
9:10 Genetic diversity in Plasmodium falciparum Sarah Volkman
9:40 New insights into P. falciparum invasion Brendan Crabb
and post-invasion events
10:10 Break
10:40 Antigenic variation through gene silencing, Kirk Deitsch
activation and cellular memory
11:10 The circumsporozoite protein revisited: Photini Sinnis
New insights based on mutational analysis
11:40 Indirect aminoacylation in the apicoplast Malcolm Gardner
12:10 Lunch
1:30 Keynote Address
Cell binding determinants of virulence Thomas Wellems
in malaria
2:15 Industrialization of malaria research: Using Elizabeth Winzeler
a systems-based approach to understand
parasite biology
Session II. Parasite / Vector Jason Rasgon
Moderator
2:45 How does Plasmodium evade the Carolina Barillas-Mury
mosquito’s immune system?
3:15 Plasmodium development in the mosquito Oliver Billker
blood meal
3:45 Molecular interactions between the Marcelo Jacobs-Lorena
mosquito and the malaria parasite
4:15 Break
4:45 Is there a future for non-insecticidal malaria Bart Knols
vector control?
5:15 Complement-like antimalaria responses in Elena Levashina
A. gambiae
5:45 Genetically modified mosquitoes and the Charles Taylor
Concorde: Is it time for reevaluation?
6:30 Posters, wine and hors d’oeuvres reception
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Tuesday, March 18
8:00 Continental Breakfast
Session III. Pathogenesis and Immunity Susan Kraemer
Moderator
8:30 Mechanism of placental malaria cytoadherence: Channe Gowda
What is known and what remains to be resolved?
9:00 Functional characterization of human monoclonal Lars Hviid
antibodies specific for PfEMP1 involved in the
pathogenesis of pregnancy-associated malaria
9:30 Functional properties of effector memory Fidel Zavala
CD8+ T cells against malaria liver stages
10:00 Break
10:30 Nitric oxide, arginine, and severe malaria J. Brice Weinberg
11:00 Immunization to target parasite development Nirbhay Kumar
in the mosquito
11:30 Lunch
Session IV. Treatment and Control Sean Prigge
Moderator
1:00 Insights into targeting mitochondrial functions Akhil Vaidya
by antimalarial drugs
1:30 Characterization of a potential drug target: Daniel Goldberg
Plasmodium calpain
2:00 Quinoline drug resistance in the malarial parasite Paul Roepe
P. falciparum: Pharmacology, physiology and fitness
2:30 Break
3:00 Introduction to PlasmoDB Brian Brunk
4:00 Adjourn General Session
4:30 - PlasmoDB Workshop Brian Brunk
5:30
4:30 - JHMRI External Advisory Board meeting
6:00
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