Gene Array Core

The main function of the Gene Array Core Facility is to support JHMRI investigators who wish to apply global gene expression analysis to the study of host-parasite relationships.

Since it was established in 2002, the JHMRI Gene Array Core has met the goal of enabling and assisting the progress of public health research worldwide through gene expression, genotyping and proteomic studies in a variety of experimental models.

This Core conducts pilot experiments to generate data for grant applications, training experiments for students and, to date, has supported or participated in over 70 studies, including:

• Study of the genetic and hormonal mechanism mediating gender differences in Plasmodium infection
  

• Study of the alteration of expression in CD4 T cells following malaria infection
  

• Cerebral and pulmonary expression changes after malaria infection in susceptible and resistant strains of mice

[IMAGE] A key accomplishment of the Gene Array Core was the design of an Affymetrix GeneChip© containing the full genomes of both Anopheles gambiae and Plasmodium falciparum. JHMRI investigators have played an integral part in establishing the utility of the chip for the worldwide malaria community.

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LINKS

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