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Publications
Kappe SH, Buscaglia CA, Bergman LW, Coppens I, Nussenzweig V. Apicomplexan gliding motility and host cell invasion: overhauling the motor model. Trends Parasitol 20:13-16, 2004.
Kaiser K, Camargo N, Coppens I, Morrisey JM, Vaidya AB, Kappe SH. member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites. MolBiochemParasitol. 133(1):15-26, 2004.
Vielemeyer O, McIntosh MT, Joiner KA, Coppens I. Neutral lipid synthesis and storage in the intraerythrocytic stages of Plasmodium falciparum . Mol Biochem Parasitol 135:197-209, 2004.
Yang M, Coppens I, Wormsley S, Baevova P, Hoppe HC, Joiner KA. The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation. J Cell Sci 117:3831-3838, 2004.
Bhanot P, Schauer K, Coppens I, Nussenzweig V. A surface phospholipase is involved in the migration of plasmodium sporozoites through cells. J Biol Chem 280:6752-6760, 2005.
Coppens I, Vielemeyer O.Insights into unique physiological features of neutral lipids in Apicomplexa: from storage to potential mediation in parasite metabolic activities. Int J Parasitol. 2005 May;35(6):597-615. Epub 2005 Mar 19. Review.
Pal-Bhowmick I; Mehta M; Coppens I; Sharma S; Jarori GK Protective properties and surface localization of Plasmodium falciparum enolase. Infection and immunity 2007;75(11):5500-8.
Bano N., Romano J.D., Jayabalasingham B. and Coppens I. Cellular interactions of Plasmodium liver stage with its host mammalian cell. Int. J. Parasitol. 37:1329-1341.2007
Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, Labaied M, Coppens I and Kappe SH. Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Mol. Microbiol. 2008. 69:152-63.
Romano JD, Bano N and Coppens I. New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma. Cell. Microbiol. 2008. 10:465-476.
Brydges SD, Harper JM, Parussini F, Coppens I and Carruthers VB. A transient forward-targeting element for microneme-regulated secretion in Toxoplasma gondii. Biol Cell. 2008. 100:253-264.
Ng CG, Coppens I, Govindarajan D, Pisciotta J, Shulaev V and Griffin DE. Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity. Proc. Natl Acad. Sci. USA 2008. 105:16326-16331.
Srinivasan P, Coppens I, Jacobs-Lorena M. Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis. PLoS Pathog. 2009. 5:e1000262.
Lige B, Jayabalasingham B, Zhang H, Pypaert M and Coppens I. Role of an ancestral D-bifunctional protein containing two sterol-carrier protein-2 domains in lipid uptake and trafficking in Toxoplasma. Mol. Biol. Cell. 2009. 20:658-672.
Kafsack BFC, Pena JDO, Coppens I, Ravindran, S, Boothroyd JC and Carruthers VB. A perforin-like protein facilitates Toxoplasma egress. Science 2009 323:530-533.
Goldszmid RS, Coppens I, Avital L, Mellman I and Sher A. Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation of Toxoplasma infected dendritic cells. J. Exp. Med. 2009. 184:i4.
Abraham EG, Islam S, Srinivasan P, Ghosh AK, Valenzuela J, Ribeiro JMC, Kafatos FC, Dimopoulos G, Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptional repertoires during ookinete development and midgut invasion. J Biol Chem 279:5573-5580, 2004.
Srinivasan P, Abraham EG, Ghosh AK, Valenzuela J, Ribeiro JMC, Dimopoulos G, Kafatos FC, Adams JH, Fujioka H, Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation. J Biol Chem 279:5581-5587, 2004.
Aguilar R, Dong Y, Warr E, Dimopoulos G. Anopheles infection responses; laboratory models versus field malaria transmission systems. Acta Trop 95:285-91, 2005.
Both M, Eckert SE, Csukai M, Muller E, Dimopoulos G, Spanu PD. Transcript profiles of Blumeria graminis development during infection reveal a cluster of genes that are potential virulence determinants. Mol Plant Microbe Interact 18:125-133, 2005.
Heard NA, Holmes CC, Stephens DA, Hand DJ, Dimopoulos G. Bayesian coclustering of Anopheles gene expression time series: Study of immune defense response to multiple experimental challenges. Proc Natl Acad Sci USA 102:16939-44, 2005.
Xu X, Dong Y, Abraham EG, Kocan A, Srinivasan P, Ghosh AK, Sinden RE, Ribeiro JM, Jacobs-Lorena M, Kafatos FC, Dimopoulos G. Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol Biochem Parasito 142:76-87, 2005.
Ruth Aguilar, Anne E. Jedlicka, Margaret Mintz, Vassiliki Mahairaki, Alan L. Scott and George Dimopoulos. (2005) Global gene expression analysis of Anopheles gambiae responses to microbial challenge. Insect Biochem Mol Biol. ;35:709-719.
Warr, E., Lambrechts, L., Bourgouin C., Koella, J., and Dimopoulos G. (2006) Melanization of Sephadex Beads in Anopheles gambiae is controlled by anti-Plasmodium immune factors. Insect Biochemistry and Molecular Biology, 36:769-778
Baton, L., Dong, Y., Li, J. and Dimopoulos G. (2006) Variation in mosquito immunity to Plasmodium . Proceedings of the 11th International Congress of Parasitology
Mair G., Braks J.A.M., Garver L., Wiegant J.K.A.G., Hall Dirks, R.W., Khan S.M., Dimopoulos G., Janse C.J., Waters A.P. (2006) Regulation of sexual development of Plasmodium by translational repression. Science , 313(5787):667-669.
Dong Y., Taylor H.E., and Dimopoulos G. (2006) AgDscam, a hyper variable immunoglobulin domain containing receptor of the Anopheles gambiae innate immune system. PLoS Biology 4: e229
Aguilar, R., Das, S., Dong, Y. and Dimopoulos, G. (2007) Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system. BMC Genomics, 8:451.
Dong Y., Aguilar R., Xi Z., Warr E., Mongin E., and Dimopoulos, G. (2006) Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. PLoS Pathogens 6: 1-13.
Cernetich A, Garver LS, Jedlicka AE, Klein PW, Kumar N, Scott AL, Klein SL. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun. 2006 Jun;74(6):3190-203.
Mlambo G, Kumar N. A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas. Exp Parasitol. 2007 Feb;115(2):211-4. Epub 2006 Sep 20.
Pisciotta JM, Coppens I, Tripathi AK, Scholl PF, Shuman J, Bajad S, Shulaev V, Sullivan DJ. The role of neutral lipid nanospheres in Plasmodium falciparum heme crystallization.Biochem J. 2006 Oct 17; PMID:1704481
Waterhouse Robert M; Kriventseva Evgenia V; Meister Stephan; Xi Zhiyong; Alvarez Kanwal S; Bartholomay Lyric C; Barillas-Mury Carolina; Bian Guowu; Blandin Stephanie; Christensen Bruce M; Dong Yuemei; Jiang Haobo; Kanost Michael R; Koutsos Anastasios C; Levashina Elena A; Li Jianyong; Ligoxygakis Petros; Maccallum Robert M; Mayhew George F; Mendes Antonio; Michel Kristin; Osta Mike A; Paskewitz Susan; Shin Sang Woon; Vlachou Dina; Wang Lihui; Wei Weiqi; Zheng Liangbiao; Zou Zhen; Severson David W; Raikhel Alexander S; Kafatos Fotis C; Dimopoulos George; Zdobnov Evgeny M; Christophides George K Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science (New York, N.Y.) 2007;316(5832):1738-43.
Baton, L., Warr, E., Hoffman S. and Dimopoulos, G. (2007) Programmed cell death during malaria parasite infection of the vertebrate host and mosquito vector. In Programmed Cell Death in Protozoa, Edited by Martin P. Landes Bioscience, Springer.
Garver Lindsey S; Xi Zhiyong; Dimopoulos George Immunoglobulin superfamily members play an important role in the mosquito immune system. Developmental and comparative immunology 2008;32(5):519-31.
Warr E; Das S; Dong Y; Dimopoulos G The Gram-negative bacteria-binding protein gene family: its role in the innate immune system of anopheles gambiae and in anti-Plasmodium defence. Insect molecular biology 2008;17(1):39-51.
Dong, Y. and Dimopoulos, G., Anopheles fibrinogen –related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites Journal of Biological Chemistry, J Biol Chem 284:9835-44.
Baton LA, Robertson A, Warr E., Strand R. and Dimopoulos G. Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium infection. BMC Genomics 10:257.
Dong Y., Manfredini F. and Dimopoulos G. Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog. 5(5):e1000423.
Das S., and Dimopoulos G. (2008) Molecular analysis of photic inhibition of blood-feeding in Anopheles gambiae. BMC Physiology 16;8(1):23.
Xi Z., Ramirez JL., Dimopoulos G. (2008) The Aedes aegypti Toll pathway controls dengue virus infection. PLoS Pathog.4(7).
Ramirez José L; Garver Lindsey S; Dimopoulos George Challenges and approaches for mosquito targeted malaria control. Current molecular medicine 2009;9(2):116-30.
Garver LS., Dong Y., and Dimopoulos G. (2009) Caspar control resistant to Plasmodium falciparum in diverse Anopheline species. PLoS Pathogens. PLoS Pathog. 5(3):e1000335.
Nezami A, Freire E. The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors. Int J Parasitol 32:1669-1676, 2002.
Nezami A, Luque I, Kimura T, Kiso Y, Freire E. Identification and characterization of allophenylnorstatinebased inhibitors of plasmepsin II, an anti-malarial target. Biochem 41:2273-2280, 2002.
Bower, E., Bacha, U.M., Kawasaki, Y. and Freire, E. Inhibition of HIV-2 Protease by HIV-1 Protease Inhibitors in Clinical Use (2008) Chem. Biol. Drug. Design 71 298-305
Cremades, N., Velazquez-Campoy, A., Freire, E. and Sancho, J. The Flavodoxin from Helicobacter pylori: Structural Determinants of Thermostability and FMN Cofactor Binding (2008) Biochemistry 47 627-639
Hosahudya Gopi, M.Umashankara, Vanessa Pirrone, Judith LaLonde, Navid Madani, Ferit Tuzer, Sabine Baxter, Isaac Zentne, Simon Cocklin, Navneet Jawanda, Shendra R. Miller, Arne Schön, Jeffrey C. Klein, Ernesto Freire, Fred C. Krebs, Amos B. Smith III, Joseph Sodroski and Irwin Chaiken (2008) Structural Determinants for Affinity Enhancement of a Dual Antagonist Peptide Entry Inhibitor of Human Immunodeficiency Virus Type-1 J. Medicinal Chem. 51 2638-2647
Ruben, A. J., Kiso, Y. and Freire, E. (2006) Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective. Chemical Biology & Drug Design 67 2-4.
Ruben AJ, Freire E. The Plasmepsin Family as Antimalarial Drug Targets. In Proteases as Drug Targets: Aspartic Acid Proteases, J. Vacca, Ed. Wiley-VCH Verlag GmbH & Co. KGaA.
Bacha, U., Barrila, J., Gabelli, S.B., Kiso, Y. Amzel, L.M. Freire, E. (2008) Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro Chem. Biol. Drug. Design 72, 34-49
Freire, E. A new era for microcalorimetry in drug development (2008) American Pharmaceutical Review 11, 118-123
Freire, E. (2008) Do Enthalpy and Entropy Distinguish First in Class From Best in Class? Drug Discovery Today 13, 869-874
Navid Madani, Arne Schon, Amy M. Princiotto, Judith M. LaLonde, Joel R. Courter, Takahiro Soeta, Danny Ng, Liping Wang, Evan T. Brower, Shi-Hua Xiang, Young Do Kwon, Chih-chin Huang, Richard Wyatt, Peter D. Kwong, Ernesto Freire, Amos B. Smith III and Joseph Sodroski (2008) Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120. Structure 16, 1689-1701
Hidaka, K., Kimura, T., Ruben, A. J., Uemura, T., Kamiya, M., Kiso, A., Okamoto, T., Tsuchiya, Y., Hayashi, Y., Freire, E. and Kiso, Y. (2008) Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorganic and Medicinal Chemistry, 16:10049-60.
Freire, E . A Thermodynamic Platform for Drug Discovery and Optimization (2008) in Towards Drugs of the Future, pages 13-22 Kruse, C.G. and Timmerman, H. Eds.
Freire, E., Schön, A., Velazquez-Campoy, A. (2009) Isothermal Titration Calorimetry: General Formalism Using Binding Polynomials. Methods Enzymol 455:127-55.
Freire, E. ITC: Affinity is not everything (2009) European Pharmaceutical Review 14, 44-47
Brower, E. T., Schon, A., Klein, J. C., and Freire, E. Binding Thermodynamics of the N-Terminal Peptide of the CCR5 Coreceptor to HIV-1 Envelope Glycoprotein gp120 (2009) Biochemistry 48, 779-785
Pekosz, A & GE Glass. Emerging viral diseases. Maryland Med 2008:9:11-16
Walsh, AS, GE Glass, CR Lesser & FC Curriero. Predicting seasonal abundance of mosquitoes based on off-season meteorological conditions. Environ Ecol Statistics 2008:15:279-291
Johansson MA, GE Glass. High-resolution spatiotemporal weather models for climate studies. Int J Health 2008:Geogr7:Article 52
Johansson, MA, F Dominici, GE Glass. Local and global effects of climate on dengue transmission in Puerto Rico. PLoS NTD 2009: 3(2): e382. doi:10.1371/journal.pntd.0000382
Vittor, A. W. Pan, R. Gilman, J.Tielsch, GE Glass, T. Shields, W. Sánchez-Lozano, V. Pinedo, E. Salas-Cobos, J. Patz.2009. Linking deforestation to malaria in the Amazon: Characterization of the breeding habitat of the principal malaria vector, Anopheles darlingi Am J Trop Med Hyg 81:5-12.
Gardner-Santana, L.C., Norris, D.E., Fornadel, C.M. Hinson, E.R., Klein, S.L., Glass, GE. 2009. Commensal ecology, urban landscapes, and their influence on the genetic characteristics of city-dwelling Norway rats (Rattus norvegicus). Molecular Ecology 18:2766-78.
Ghosh A, Srinivasan P, Abraham EG, Fujioka H, Jacobs-Lorena M. Molecular strategies to study Plasmodium -mosquito interactions. Trends Parasitol 19:94-101, 2003.
Riehle MA, Srinivasan P, Moreira CK, Jacobs-Lorena M. Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges. J Exp Biol 206:3809-3816, 2003.
Villalón JM, Ghosh A, Jacobs-Lorena M. The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes. J Insect Physiol 49:891-895, 2003.
Moreira CK, Marrelli MT, Jacobs-Lorena M. Gene expression in Plasmodium : from gametocytes to sporozoites. Int J Parasitol 34:1431-1440, 2004.
Abraham EG, Jacobs-Lorena M. Mosquito midgut barriers to malaria parasite development. Insect Biochem Mol Biol 34:667-671, 2004.
Devenport M, Fujioka H, Jacobs-Lorena M. Storage and secretion of the peritrophic matrix protein AgAper1 and trypsin in the midgut of Anopheles gambiae . Insect Mol Biol 13:349-358, 2004.
Moreira LA, Wang J, Collins FH, Jacobs-Lorena M. Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development. Genetics 166:1337-1341, 2004.
Brotto MA, Marrelli MT, Brotto LS, Jacobs-Lorena M, Nosek TM. Functional and Biochemical Modifications in Skeletal Muscles from Malarial Mice. Exp Physiol Feb 22, 2005.
Abraham EG, Donnelly-Doman M, Fujioka H, Ghosh A, Moreira L, Jacobs-Lorena M. Driving midgut-specific expression and secretion of a foreign protein in transgenic mosquitoes with AgAper1 regulatory elements. Insect Mol Biol 14:271-279, 2005.
Abraham EG, Pinto SB, Ghosh A, Vanlandingham DL, Budd A, Higgs S, Kafators FC, Jacobs-Lorena M, Michel K. An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proc Natl Acad Sci USA 102:16327-16332, 2005.
Abraham EG, Pinto SB, Ghosh A, Vanlandingham DL, Budd A, Higgs S, Kafatos FC, Jacobs-Lorena M, Michel K. An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16327-32. Epub 2005 Oct 31.
Devenport M, Alvarenga PH, Shao L, Fujioka H, Bianconi ML, Oliveira PL,Jacobs-Lorena M. Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein. Biochemistry. 2006 Aug 8;45(31):9540-9.
Marrelli MT, Moreira CK, Kelly D, Alphey L, Jacobs-Lorena M. Mosquito transgenesis: what is the fitness cost? Trends Parasitol. 2006 May;22(5):197-202. Epub 2006 Mar 24. Review.
Kanzok SM, Jacobs-Lorena M. Entomopathogenic fungi as biological insecticides to control malaria. Trends Parasitol. 2006 Feb;22(2):49-51. Epub 2005 Dec 27. Review.
Dinglasan RR, Alaganan A, Ghosh AK, Saito A, van Kuppervelt TH and Jacobs-Lorena M (2007) Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion. Proc. Natl. Acad. Sci. USA.
Sodja A, Fujioka H, Lemos FJA, Donnelly-Doman M and Jacobs-Lorena M (2007) Induction of actin gene expression in the mosquito midgut by blood ingestion correlates with striking changes of cell shape. J. Insect Physiol. 53:833-839.
Dinglasan RR, Kalume DE, Kanzok SM, Ghosh AK, Muratova O, Pandey A and Jacobs-Lorena M (2007) Characterization of a novel, conserved Plasmodium transmission-blocking mosquito midgut antigen. Proc. Natl. Acad. Sci. USA 104:13461-13466.
Moreira CK, Rodrigues FG, Ghosh A, Varotti FP, Miranda A, Daffre S, Jacobs-Lorena M and Moreira LA (2007) Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp. Exp. Parasit., 116:346-353.
Marrelli MT, Li C, Rasgon J and Jacobs-Lorena M (2007) Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood. Proc. Natl. Acad. Sci. USA. 104:55805583.
Riehle MA, Moreira CK, Lampe D, Lauzon C and Jacobs-Lorena M (2007) Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut. Int. J. Parasit. 37:595-603.
Srinivasan Prakash; Fujioka Hisashi; Jacobs-Lorena Marcelo PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito. Cellular microbiology 2008;10(6):1304-12.
Dinglasan Rhoel R; Jacobs-Lorena Marcelo Flipping the paradigm on malaria transmission-blocking vaccines. Trends in parasitology 2008;24(8):364-70.
Li Chaoyang; Marrelli Mauro T; Yan Guiyun; Jacobs-Lorena Marcelo; Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. The Journal of heredity 2008;99(3):275-82.
Srinivasan Prakash; Coppens Isabelle; Jacobs-Lorena Marcelo; Distinct roles of Plasmodium rhomboid 1 in parasite development and malaria pathogenesis.PLoS pathogens 2009;5(1):e1000262.
Vega-Rodríguez Joel; Franke-Fayard Blandine; Dinglasan Rhoel R; Janse Chris J; Pastrana-Mena Rebecca; Waters Andrew P; Coppens Isabelle; Rodríguez-Orengo José F; Jacobs-Lorena Marcelo; Serrano Adelfa E The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS pathogens 2009;5(2):e1000302.
Dinglasan R R; Devenport M; Florens L; Johnson J R; McHugh C A; Donnelly-Doman M; Carucci D J; Yates J R; Jacobs-Lorena M, The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect biochemistry and molecular biology 2009;39(2):125-34.
González-Lázaro M, Dinglasan RR, Hernández-Hernández FD, Rodríguez MH, Laclaustra M, Jacobs-Lorena M, Flores-Romo L. L.Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei.Insect Biochem Mol Biol. 2009:Apr 12.
Ghosh Anil K; Devenport Martin; Jethwaney Deepa; Kalume Dario E; Pandey Akhilesh; Anderson Vernon E; Sultan Ali A; Kumar Nirbhay; Jacobs-Lorena Marcelo Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS pathogens 2009;5(1):e1000265.
Sanchez G, Sedegah M, Rogers WO, Jones T, Sacci J, Witney A, Carucci D, Kumar N, Hoffman S. Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice. Inf and Immun 69:3897-3905, 2001.
Bhattacharyya M, Kumar N. Effect of xanthurenic acid on infectivity of Plasmodium falciparum to Anopheles stephensi . Int J Parasitol 31:1129-1133, 2001.
Bhattacharyya M, Hong Z, Kongkasuriyachai D, Kumar N. Plasmodium falciparum protein phosphatase Type 1 functionally complements a glc7 mutant in Saccharomyces cerevisa. Int J Parasitol 32:739-747, 2002.
Kongkasuriyachai D, Kumar N. Functional characterization of sexual stage specific proteins in Plasmodium falciparum. Int J Parasitol 32:1559-1566, 2002.
Haddad D, Kumar N. The expanding universe of "Omes": approaches to malaria drugs and vaccine design. Recent Research Developments in Inf Immun 1:419-432, 2003.
Kashamuka M, Nzila N, Mussey L, Lubaki N, Quinn TC, Bollinger R, Kumar N. Short report: analysis of antimalaria immune response during human immunodeficiency virus infection in adults in Kinshasa, Democratic Republic of Congo. Am J Trop Med Hyg 68:376-378, 2003.
Coban C, Kumar N. Malaria DNA vaccines. Curr Trends in Immunol 5:19-31, 2003.
Dhar R, Kumar N. Role of mosquito salivary glands. Current Science 85:101-106, 2003.
Kongkasuriachai D, Fujioka H, Kumar N. Functional analysis of Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16) during gametocytogenesis and gametogenesis by targeted gene disruption. Mol Biochem Parasitol 133:275-285, 2004.
Kumar N, Cha G, Pineda F, Maciel J, Haddad D, Bhattacharyya M, Nagayasu E. Molecular complexity of sexual development and gene regulation in Plasmodium falciparum . Int J Parasitol 34:1451-1458, 2004.
Scott C, Kumar N, Bishai W, Manabe Y. Short Report: Modulation of MycobacteriumTuberculosis infection by Plasmodium in the murine model. Am J Trop Med Hyg 70:144-148, 2004.
Coban C, Ishii K, Stowers A, Keister D, Klinmann D, Kumar N. Effect of CpG oligonucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission blocking vaccine antigen. Inf Immun 72:584-588, 2004.
Coban C, Phillip M, Purcell JE, Keister D, Okulate M, Martin DS, Kumar N. Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations. Inf Immun 72:253-259, 2004.
Kalume DE, Peri S, Reddy R, Zhong J,Okulate M, Kumar N, Pandey A. Genome annotation of Anopheles gambiae using mass spectrometry-derived data. BMC Genomics 19;6:128, 2005.
Coban C, Ishii KJ, Gursel M, Klinman DM, Kumar N. Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors. J Leukoc Biol. 2005 Sep;78(3):647-55. Epub 2005 Jun 16.
Kalume DE, Okulate M, Zhong J, Reddy R, Suresh S, Deshpande N, Kumar N, Pandey A. A proteomic analysis of salivary glands of female Anopheles gambiae mosquito. Proteomics. 2005 Sep;5(14):3765-77.
Noland GS, Graczyk TK, Fried B, Fitzgerald EJ, Kumar N. Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment. J Parasitol. 2005 Aug;91(4):944-8.
Page KR, Jedlicka AE, Fakheri B, Noland GS, Kesavan AK, Scott AL, Kumar N, Manabe YC. Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specific. Infect Immun 73:8369-8380, 2005.
Mlambo G, Kumar N. A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas. Exp Parasitol. 2007 Feb;115(2):211-4. Epub 2006 Sep 20.
Mlambo G, Mutambu SL, Mduluza T, Soko W, Mbedzi J, Chivenga J, Lanar DE,Singh S, Carucci D, Gemperli A, Kumar N. Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude.Acta Trop. 2006 Nov;100(1-2):70-78. Epub 2006 Nov 17.
Haddad D, Maciel J, Kumar N. Infection with Plasmodium berghei boosts antibody responses primed by a DNA vaccine encoding gametocyte antigen Pbs48/45. Infect Immun. 2006 Apr;74(4):2043-51.
Mlambo G, Sullivan D, Mutambu SL, Soko W, Mbedzi J, Chivenga J, Jaenisch T, Gemperli A, Kumar, N, Analysis of genetic polymorphism in select vaccine candidate antigens and microsatellite loci in Plasmodium falciparum from endemic areas at varying altitudes.Acta Trop. 2007 Jun;102(3):201-5.
Noland Gregory S; Graczyk Thaddeus K; Fried Bernard; Kumar Nirbhay. Enhanced malaria parasite transmission from helminth co-infected mice. The American journal of tropical medicine and hygiene 2007;76(6):1052-6.
Liu Yangjian; Promeneur Dominique; Rojek Aleksandra; Kumar Nirbhay; Frøkiaer Jørgen; Nielsen Søren; King Landon S; Agre Peter; Carbrey Jennifer M. Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence.
Mlambo Godfree; Sullivan David; Mutambu Susan L; Soko White; Mbedzi Joel; Chivenga James; Gemperli Armin; Kumar Nirbhay High prevalence of molecular markers for resistance to chloroquine and pyrimethamine in Plasmodium falciparum from Zimbabwe.
Okulate M A; Kalume D E; Reddy R; Kristiansen T; Bhattacharyya M; Chaerkady R; Pandey A; Kumar N Identification and molecular characterization of a novel protein Saglin as a target of monoclonal antibodies affecting salivary gland infectivity of Plasmodium sporozoites. Insect molecular biology 2007;16(6):711-22.
LeBlanc Ralph; Vasquez Yessika; Hannaman Drew; Kumar, Nirbhay; Markedly enhanced immunogenicity of a Pfs25 DNA-based malaria transmission-blocking vaccine by in vivo electroporation. Vaccine 2008;26(2):185-92.
Ellekvist Peter; Maciel Jorge; Mlambo, Godfree; Ricke Christina H; Colding Hanne; Klaerke Dan A; Kumar, Nirbhay Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption. Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6398-402.
Mlambo, Godfree; Maciel Jorge; Kumar, Nirbhay Murine model for assessment of Plasmodium falciparum transmission-blocking vaccine using transgenic Plasmodium berghei parasites expressing the target antigen Pfs25. Infection and immunity 2008;76(5):2018-24.
Mlambo, Godfree; Kumar, Nirbhay Transgenic rodent Plasmodium berghei parasites as tools for assessment of functional immunogenicity and optimization of human malaria vaccines. Eukaryotic cell 2008;7(11):1875-9.
Noland GS, Urban JF Jr, Fried B, Kumar N. Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice.Exp Parasitol. 2008 Jun;119(2):272-8. Epub 2008 Mar 7.
Mahajan Babita; Selvapandiyan Angamuthu; Gerald Noel J; Majam Victoria; Zheng Hong; Wickramarachchi Thilan; Tiwari Jawahar; Fujioka Hisashi; Moch J Kathleen; Kumar, Nirbhay; Aravind L; Nakhasi Hira L; Kumar Sanjai Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum. The Journal of biological chemistry 2008;283(46):31871-83.
Ghosh Anil K; Devenport Martin; Jethwaney Deepa; Kalume Dario E; Pandey Akhilesh; Anderson Vernon E; Sultan Ali A; Kumar, Nirbhay; Jacobs-Lorena Marcelo Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins.PLoS pathogens 2009;5(1):e1000265.
Nyunt MM, Hendrix CW, Bakshi RP, Kumar N, Shapiro TA.Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.Am J Trop Med Hyg. 2009 Apr;80(4):528-35.
Chen Xiaochun; Xie Suji; Bhat Shridhar; Kumar, Nirbhay; Shapiro, Theresa A; Liu Jun O
Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chemistry & biology 2009;16(2):193-202.
Sangweme D, Shiff C, Kumar N, Plasmodium yoelii: Adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model. Exp arasitol. 2009 Apr 12. 2009.
Mharakurwa S, Simoloka C, Thuma PE, Shiff CJ, Sullivan DJ. PCR detection of Plasmodium falciparum in human urine and saliva samples. Malar J. 2006 Nov 8;5:103
Norris DE, Shurtleff AC, Touré YT, Lanzaro GC. Microsatellite DNA polymorphism and heterozygosity among field and laboratory populations of Anopheles gambiaes.s. (Diptera: Culicidae). J Med Entomol 38:336-340, 2001.
Taylor C, Touré YT, Carnahan J, Norris DE, Dolo G, Traore SF, Edillo FE, Lanzaro GC. Gene flow among populations of the malaria vector, Anopheles gambiae , in Mali, West Africa. Genetics 157:743-750, 2001.
Tripet F, Touré YT, Taylor CE, Norris DE, Dolo G, Lanzaro GC. DNA analysis of transferred sperm reveals significant levels of gene flow between molecular forms of Anopheles gambiae . Mol Ecol 10:1725-1732, 2001.
Koekemoer, L.L., E.A. Misiani, R.H. Hunt, R.J. Kent, D.E. Norris and M. Coetzee. Cryptic species within Anopheles longipalpis Theobald from southern Africa and phylogenetic comparison with members of the An. Funestus. Bull Entomol Res 99:41-9.
Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. J Med Chem. 2008 Feb 28;51(4):1035-42. Epub 2008 Jan 31.
Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH.Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells.J Med Chem. 2009 Feb 2. [Epub ahead of print]
Lee PJ, Bhonsle JB, Gaona HW, Huddler DP, Heady TN, Kreishman-Deitrick M, Bhattacharjee A, McCalmont WF, Gerena L, Lopez-Sanchez M, Roncal NE, Hudson TH, Johnson JD, Prigge ST, Waters NC. Targeting the Fatty Acid Biosynthesis Enzyme, beta-Ketoacyl-Acyl Carrier Protein Synthase III (PfKASIII), in the Identification of Novel Antimalarial Agents.J Med Chem. 2009 Feb 3. [Epub ahead of print]
Spalding MD and Prigge ST, Malaria pulls a FASt one. Cell Host & Microbe, 2008:4, 509-511.
Lu JZ and Prigge ST, The tail of mycolic acids. Chem. Biol. 2008:4, 309-310.
Allary M and Prigge ST, Fatty Acid Synthesis in Protozoan Parasites. In: Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Ltd: Chichester (2008).
Rasgon JL, Ren X, Petridis M. Can Anopheles gambiae be infected with Wolbachia pipientis? Insights from an in vitro system.Appl Environ Microbiol. 2006 Dec;72(12):7718-22. Epub 2006 Oct 6
Dunning-Hotopp JC and Rasgon JL. Bacterial sequences in an invertebrate genome. Microbiology Today. 2008: Nov: 176-179.
Ren X, Hoiczyk E and Rasgon JL. Viral paratransgenesis in the malaria vector Anopheles gambiae. PLoS Pathogens, 2008:4: e1000135.
Rasgon JL. Wolbachia and Anopheles mosquitoes. In Insect symbiosis, vol. 3. Eds. K. Bourtzis and T. Miller. CRC Press, Boca Raton, FL. Ch. 14, 321-372.
Wong J, Tripet F, Rasgon JL, Lanzaro GC and Scott TW. SSCP analysis of scnDNA for genetic profiling of Aedes aegypti. Am. J. Trop. Med. Hyg., 2008:79: 511-517.
Rasgon JL. Using predictive models to optimize Wolbachia-based strategies for vector-borne disease control. Adv. Exp. Med. Biol. 2008: 627: 114-125.
Billingsley PF, Foy B and Rasgon JL. Mosquitocidal vaccines: a neglected addition to malaria and dengue control strategies. Trends in Parasitology, 2008:24: 396-400.
Rasgon JL. Stable isotope analysis can potentially identify completely-digested bloodmeals in mosquitoes. PLoS ONE 2008:3: e2198.
Venkatesan M, Broman KW, Sellers M and Rasgon JL. 2009. An initial linkage map of the West Nile Virus vector Culex tarsalis. Insect Molecular Biology. EPub ahead of print.
Jin C, Ren X and Rasgon JL. The virulent Wolbachia strain wMelPop efficiently establishes somatic infections in the malaria vector Anopheles gambiae. Applied and Environmental Microbiology. 2009:75: 3373-3376.
Christian F. Ockenhouse, Wan-chung Hu, Kent E. Kester, James F. Cummings, Ann Stewart, D. Gray Heppner, Anne E. Jedlicka, Alan L. Scott, Nathan D. Wolfe, Maryanne Vahey, and Donald S. Burke Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria. Infection and Immunity, Oct. 2006, p. 5561–5573
Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.J Med Chem. 2006 May 4;49(9):2731-4.
Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay PT. Induction of the Phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev 2007:16:847-51
Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA . Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. J Med Chem 2007:50:2516-9
Scocca JR, Shapiro TA. A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes. Mol Microbiol 2008:67:820-9
Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. J Med Chem 2008:51:1035-42
Bakshi RP, Sang D, Morrell A, Cushman M, Shapiro TA. Activity of indenoisoquinolines against African trypanosomes. Antimicrob Agents Chemother 2009:53:123-8
Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol 2009:16:193-202
Nyunt MM, Hendrix CW, Bakshi RP, Kumar N, Shapiro TA Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites. Am J Trop Med Hyg 2009:80:528-35
Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH (2009) Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. J Med Chem. 52:1198-203.
Tripathi AK, Sullivan DJ, Stins MF.Plasmodium falciparum-infected erythrocytes increase intercellular adhesion molecule 1 expression on brain endothelium through NF-kappaB.Infect Immun. 2006Jun;74(6):3262-70.
Hiremath GS, Sullivan DJ Jr, Tripathi AK, Black RE, Sazawal S.Effect of Plasmodium falciparum parasitemia on erythrocyte zinc protoporphyrin.Clin Chem. 52(4):778-9 (2006)
Chen X, Chong CR, Shi L, Yoshimoto T, Sullivan DJ Jr, Liu JO.Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14548-53. Epub 2006 Sep 18.
Szklarczyk A, Stins M, Milward EA, Ryu H, Fitzsimmons C, Sullivan D, Conant K. Glial activation and
matrix metalloproteinase release in cerebral malaria.J Neurovirol. 2007;13(1):2-10. Review.
Chong CR, Qian DZ, Pan F, Wei Y, Pili R, Sullivan DJ Jr, Liu JO. Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem. 49(9):2677-80 (2006).
Mlambo G, Vasquez Y, LeBlanc R, Sullivan DJ Jr,, Kumar N. A filter paper method for the detection of Plasmodium falciparum gametocytes by reverse transcription polymerase chain reaction. Am J Trop Med Hyg. 2008: Jan;78(1):114-6.
Brahmbhatt H, Sullivan DJ Jr, Kigozi G, Askin F, Wabwire-Mangenm F, Serwadda D, Sewankambo N, Wawer M, Gray R. Association of HIV and malaria with mother-to-child transmission, birth outcomes, and child mortality. J Acquir Immune Defic Syndr. 2008:47:472-6.
Kifude CM, Rajasekariah HG, Sullivan DJ Jr, Stewart VA, Angov E, Martin SK, Diggs CL, Waitumbi JN. Enzyme-linked immunosorbent assay for detection of Plasmodium falciparum histidine-rich protein 2 in blood, plasma, and serum. Clin Vaccine Immunol. 15:1012-8.(2008)
Pisciotta JM, Sullivan DJ Jr,. Hemozoin: oil versus water. Parasitol Int. 2008 57:89-96. Review.
Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, Sullivan DJ Jr,, Zavala F, Morrell CN. Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe. Aug 14;4(2):179-87(2008)
Downey AS, Chong CR, Graczyk TK, Sullivan Jr. DJ Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model. Antimicrob Agents Chemother. 2008:52:3106-12.
Abhai K Tripathi, Wei Sha, Vladimir Shulaev, Monique F Stins and David J Sullivan Jr. Plasmodium falciparum Infected Erythrocytes Induce NF-kB Regulated Inflammatory Pathways in Human Cerebral Endothelium. Blood 2009:114:4243-52.
Morrot A, Cockburn IA, Overstreet M, Rodriguez D, Zavala F. Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression.Infect Immun. 2006 Apr;74(4):2495-7.
Hafalla JC, Cockburn IA, and Zavala F. 2006. Protective and Pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol. 28:15-24.
Boscardin AB, Hafalla JCR, Masilamani RF, Kamphorst, AO, Zebroski, HA Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig, RS and Nussenzweig MC. 2006. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J. Exp. Med. 203: 599-606.
Hafalla JC, Urvashi Rai, Alexandre Morrot, Dabeiba Bernal-Rubio, Fidel Zavala and Ana Rodriguez.2006 Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur. J Immunol 36:1179-86.
Kumar K A, Sano GI, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F and Nussenzweig V.2006 The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature 444 (7121):937-40.
Srivastava S K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher C A , Shirk EM., Sun H, Kowalska A, Fox-Talbot K, Sullivan D, Lowenstein C J , Zavala F and Morrell CN. Platelet Factor 4 Mediates Inflammation in Cerebral Malaria. Cell Host Microbe. 2008:4:179-87.
Overstreet M, Cockburn IA., Chen YC ., Zavala F. Protective CD8+ T cell responses against malaria liver stages: Immunobiology of an “unnatural” immune response Immunol Revs. 2008:225:271-83
Chakravarty S, Baldeviano GC, Overstreet MG, Zavala F. Effector CD8+ T lymphocytes against malaria liver stages do not require IFN-{gamma} for anti-parasite activity. Infect Immun. 2008:76: 3628-31
Sinnis P, Zavala F. The skin stage of malaria infection: biology and relevance to the malaria vaccine effort. 2008. Future Microbiol. Jun;3:275-8.
Dalai SK., Mirshadidi S, Morrot A, Zavala F and Sadegh-Nasseri S. Anergy in memory CD4+ T cells in induced by B cells J. Immunol 2008:181:3221-31
Cockburn I A., Chakravarty S., Overstreet M., García-Sastre A and Zavala F. Memory CD8+ T cell responses expand when antigen presentation overcomes T-cell self-regulation. J. Immunol. 2008:180:64-71
McKelvie ND, Khan SA, Karavolos MH, Bulmer DM, Lee JJ, Demarco R, Maskell DJ, Zavala F, Hormaeche CE, Khan CM.Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen. FEMS Immunol Med Microbiol. 2008 Feb;52(2):237-46. Epub 2008 Jan 3.
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