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Structural Biology
- Jürgen Bosch and his team are exploring the structures of malarial proteins related to host-cell invasion and egress as well as to processes involved in the conversion of liver stage sporozoites into blood stage merozoites. The Bosch lab's ultimate goal is to apply structure guided drug design methods to identify small molecule inhibitors of the protein-protein interactions involved in these processes.
- Sean Prigge is focusing his research on essential metabolic pathways in the malaria parasite, particularly those required for the biosynthesis and modification of fatty acids. Several enzyme cofactors such as pantothenate, lipoic acid, biotin and iron-sulfur clusters should be required for these metabolic pathways. We are interested in these cofactors, how they are acquired, how they are used, and whether they are essential for the growth of malaria parasites.
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